Lipid droplet functions beyond energy storage

MA Welte, AP Gould - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2017 - Elsevier
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …

Lipid droplets in health and disease

G Onal, O Kutlu, D Gozuacik… - Lipids in health and …, 2017 - Springer
Lipids are essential building blocks synthesized by complex molecular pathways and
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

A Stukalov, V Girault, V Grass, O Karayel, V Bergant… - Nature, 2021 - nature.com
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …

The assembly of lipid droplets and their roles in challenged cells

WM Henne, ML Reese, JM Goodman - The EMBO journal, 2018 - embopress.org
Cytoplasmic lipid droplets are important organelles in nearly every eukaryotic and some
prokaryotic cells. Storing and providing energy is their main function, but they do not work in …

Lipid droplets finally get a little RESPECT

RV Farese, TC Walther - Cell, 2009 - cell.com
Long underappreciated as important cellular organelles, lipid droplets are finally being
recognized as dynamic structures with a complex and interesting biology. In light of this …

Lipophagy: connecting autophagy and lipid metabolism

R Singh, AM Cuervo - International journal of cell biology, 2012 - Wiley Online Library
Lipid droplets (LDs), initially considered “inert” lipid deposits, have gained during the last
decade the classification of cytosolic organelles due to their defined composition and the …

Not just fat: the structure and function of the lipid droplet

T Fujimoto, RG Parton - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and
a surface phospholipid monolayer. Recent studies have revealed many new proteins …

The known unknowns of antigen processing and presentation

JM Vyas, AG Van der Veen, HL Ploegh - Nature Reviews Immunology, 2008 - nature.com
The principal components of both MHC class I and class II antigen processing and
presentation pathways are well known. In dendritic cells, these pathways are tightly …

The lipid droplet—a well-connected organelle

Q Gao, JM Goodman - Frontiers in cell and developmental biology, 2015 - frontiersin.org
Our knowledge of inter-organellar communication has grown exponentially in recent years.
This review focuses on the interactions that cytoplasmic lipid droplets have with other …

The mammalian endoplasmic reticulum-associated degradation system

JA Olzmann, RR Kopito… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic
proteome and is accordingly endowed with specialized machinery to ensure that proteins …