Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Synapses are found in vast numbers in the brain and contain complex proteomes. We
developed genetic labeling and imaging methods to examine synaptic proteins in individual …

NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …

N-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …

Understanding the evolutionary origins of behaviour is a central aim in the study of biology
and may lead to insights into human disorders. Synaptic transmission is observed in a wide …

Despite abundant evidence from basic/preclinical research that excessive NMDAR (N-
methyl-d-aspartate receptor) stimulation is a crucial step required for brain damage following …

It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR)
excitotoxicity. We report that the toxicity of NMDAR-mediated Ca 2+ influx is differentially …

Rapid advances in sequencing technology have led to an explosive increase in the number
of genetic variants identified in patients with neurological disease and have also enabled …

The subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated
during cortical development. NMDARs are initially dominated by GluN2B (NR2B), whereas …