This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …

Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40%
of the cell volume being composed of mitochondria. Mitochondria are well established as …

Objective: To study the ionic mechanisms of electrophysiologic changes in cell excitability
and action potential duration during the acute phase of myocardial ischemia. Methods …

T-wave alternans (TWA) reflects beat-to-beat fluctuations in the electrocardiographic T-
wave, and is associated with dispersion of repolarization and the mechanisms for sudden …

Oxygen-derived free radicals have been reported to damage the sarcoplasmic reticulum
(SR) Ca2+-ATPase, potentially contributing to cellular Ca2+ overload and myocardial …

An increase in cytosolic free calcium (Cai) has been shown to occur early during ischemia in
perfused rat, ferret, and rabbit hearts. It has been proposed that this increase in Cai may …

Cyclosporin A is a potent immunosuppressant used to prevent graft rejection. The cellular
target of cyclosporin A in T lymphocytes is believed to be cyclophilin, a ubiquitous protein …

Mitochondria establish contact sites between the inner and outer membranes. The contact
sites are held together by junctional complexes of the adenine nucleotide translocase (ANT; …