[HTML][HTML] Application of metabolic engineering to enhance the content of alkaloids in medicinal plants

S Mora-Vásquez, GG Wells-Abascal… - Metabolic Engineering …, 2022 - Elsevier
Plants are a rich source of bioactive compounds, many of which have been exploited for
cosmetic, nutritional, and medicinal purposes. Through the characterization of metabolic …

Metabolic engineering of Yarrowia lipolytica for high-level production of scutellarin

P Zhang, W Wei, Y Shang, BC Ye - Bioresource Technology, 2023 - Elsevier
Scutellarin drugs have been recognized as a key item in the national development of
essential clinical emergency drugs for treating cardiovascular and cerebrovascular …

Biosynthesis of High‐Active Hemoproteins by the Efficient Heme‐Supply Pichia Pastoris Chassis

F Yu, X Zhao, J Zhou, W Lu, J Li, J Chen… - Advanced …, 2023 - Wiley Online Library
Microbial synthesis of valuable hemoproteins has become a popular research topic, and
Pichia pastoris is a versatile platform for the industrial production of recombinant proteins …

[HTML][HTML] Vitreoscilla Haemoglobin: A Tool to Reduce Overflow Metabolism

H Taymaz-Nikerel, AR Lara - Microorganisms, 2021 - mdpi.com
Overflow metabolism is a phenomenon extended in nature, ranging from microbial to cancer
cells. Accumulation of overflow metabolites pose a challenge for large-scale bioprocesses …

Transcriptome Analysis of Bacillus licheniformis for Improving Bacitracin Production

Z Wu, Y Li, Y Xu, Y Zhang, G Tao, L Zhang… - ACS synthetic …, 2022 - ACS Publications
This study aims to find the targets that may influence the production of bacitracin based on
RNA sequencing in Bacillus licheniformis. Transcriptional profiling revealed that (i) the …

[HTML][HTML] Improving Degradation of Polycyclic Aromatic Hydrocarbons by Bacillus atrophaeus Laccase Fused with Vitreoscilla Hemoglobin and a Novel Strong …

L Wang, Y Tan, S Sun, L Zhou, G Wu, Y Shao, M Wang… - Biology, 2022 - mdpi.com
Simple Summary Polycyclic aromatic hydrocarbons (PAHs) are a large group of persistent
organic pollutant chemicals that have significant carcinogenic effects on humans and …

[HTML][HTML] Improving glucose oxidase catalysis in Aspergillus niger via Vitreoscilla hemoglobin fusion protein

J Liu, Q Zhang, X Liang, R Zhang, X Huang… - Applied Microbiology …, 2024 - Springer
Oxygen is crucial for converting glucose to gluconic acid catalyzed by glucose oxidase
(Gox). However, industrial gluconic acid production faces oxygen supply limitations. To …

Efficient synthesis of 2-aryl benzothiazoles mediated by Vitreoscilla hemoglobin

Y Xu, N Zhao, F Li, H Xie, J Wu, C Wang, Z Li… - Molecular Catalysis, 2022 - Elsevier
We reported the synthesis of 2-aryl benzothiazoles catalyzed by Vitreoscilla hemoglobin
(VHb). With TBHP (tert-Butyl hydroperoxide) as oxidant, DMSO (Dimethyl sulfoxide) as …

[HTML][HTML] Detection of human annexin A1 as the novel N-terminal tag for separation and purification handle

X He, S Zhang, D Dang, T Lin, Y Ge, X Chen… - Microbial Cell …, 2023 - Springer
Background Several fusion tags for separation handle have been developed, but the fused
tag for simply and cheaply separating the target protein is still lacking. Results Separation …

[HTML][HTML] Improved Recombinant Expression of Maltogenic α-Amylase AmyM in Bacillus subtilis by Optimizing Its Secretion and NADPH Production

Y Chen, Q Xin, L Pan, B Wang - Fermentation, 2023 - mdpi.com
The maltose α-amylase AmyM from Bacillus stearothermophilus can be used for flour
modification, baked goods preservation, and maltose production. Here, we optimized the …