Simple Summary Cancer metabolism is an emerging field of investigation aimed at
identifying cancer cell vulnerabilities in order to define novel anti-cancer therapeutic …

GOT2 is at the nexus of several critical metabolic pathways in homeostatic cellular and
dysregulated cancer metabolism. Despite this, recent work has emphasized the remarkable …

Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders
and are traditionally related to oxidative phosphorylation system (OXPHOS) defects in …

The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating
catabolic conversions of NAD+ to NADH and anabolic production of aspartate, a key amino …

Anoxia halts oxidative phosphorylation (OXPHOS) causing an accumulation of reduced
compounds in the mitochondrial matrix which impedes dehydrogenases. By simultaneously …

Tissue‐engineered bone has emerged as a promising alternative for bone defect repair due
to the advantages of regenerative bone healing and physiological functional reconstruction …

Although a mechanism accounting for hyperthermic death at critical temperatures remains
elusive, the mitochondria of crucial active excitable tissues (ie heart and brain) may well be …

Tumors reprogram their metabolism to generate complex neoplastic ecosystems. Here, we
demonstrate that glioblastoma (GBM) stem cells (GSCs) display elevated activity of the …

Adaptation to chronic hypoxia occurs through changes in protein expression, which are
controlled by hypoxia-inducible factor 1α (HIF1α) and are necessary for cancer cell survival …

Muscle stem cells (MuSCs) enable muscle growth and regeneration after exercise or injury,
but how metabolism controls their regenerative potential is poorly understood. We describe …