Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Atherosclerosis (AS) is a chronic inflammatory disease, involving a pathological process of
endothelial dysfunction, lipid deposition, plaque rupture, and arterial occlusion, and is one of …

Extensive research in humans and animal models has begun to unravel the complex
mechanisms that drive the immunopathogenesis of periodontitis. Neutrophils mount an early …

Immune therapeutic exosomes, derived exogenously from dendritic cells (DCs), the
'directors' of the immune response, are receiving favorable safety and tolerance profiles in …

In general, the periodontal pathogen Porphyromonas gingivalis expresses distinct FimA and
Mfa1 fimbriae. Each of these consists of five FimA–E and five Mfa1–5 proteins encoded by …

Gut microbiota play many important roles, such as the regulation of immunity and barrier
function in the intestine, and are crucial for maintaining homeostasis in living organisms. The …

Periodontitis is the most common chronic, inflammatory oral disease that affects more than
half of the population in the United States. The disease leads to destruction of the tooth …

Atherosclerosis (AS), one of the most common types of cardiovascular disease, has initially
been attributed to the accumulation of fats and fibrous materials. However, more and more …

Background: The effects of the key pathogens and virulence factors associated with gum
disease such as Porphyromonas gingivalis (P. gingivalis) on the central nervous system is of …

Periodontitis is a disease of ageing or inflammaging, and is comorbid with other more
severe age-related chronic diseases. With advanced age comes an increase in …