With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

A new scientific frontier opened in 2009 with the start of operations of the world's first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …

Light-induced oxidation of water by photosystem II (PS II) in plants, algae and cyanobacteria
has generated most of the dioxygen in the atmosphere. PS II, a membrane-bound multi …

Cytochrome c oxidase (C c O) is an essential enzyme in mitochondrial and bacterial
respiration. It catalyzes the four-electron reduction of molecular oxygen to water and …

Protein crystallography using synchrotron radiation sources has had a tremendous impact
on biology, having yielded the structures of thousands of proteins and given detailed insight …

Intense femtosecond x-ray pulses produced at the Linac Coherent Light Source (LCLS)
were used for simultaneous x-ray diffraction (XRD) and x-ray emission spectroscopy (XES) …

X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying
macromolecules at biologically relevant temperatures. Moreover, when combined with …

We present results from experiments at the Linac Coherent Light Source (LCLS)
demonstrating that serial femtosecond crystallography (SFX) can be performed to high …

This review is focused on free-electron lasers (FELs) in the hard to soft x-ray regime. The
aim is to provide newcomers to the area with insights into: the basic physics of FELs, the …

The determination of protein crystal structures is hampered by the need for macroscopic
crystals. X-ray free-electron lasers (FELs) provide extremely intense pulses of femtosecond …