Targeting arachidonic acid pathway by natural products for cancer prevention and therapy
Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis.
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …
Health Benefits of Silybum marianum: Phytochemistry, Pharmacology, and Applications
X Wang, Z Zhang, SC Wu - Journal of agricultural and food …, 2020 - ACS Publications
Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …
Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis
CM Rigby, S Roy, G Deep, R Guillermo-Lagae… - …, 2016 - academic.oup.com
Non-melanoma skin cancers (NMSC) are a growing problem given that solar ultraviolet B
(UVB) radiation exposure is increasing most likely due to depletion of the atmospheric …
(UVB) radiation exposure is increasing most likely due to depletion of the atmospheric …
[HTML][HTML] Mechanistic insights into the pharmacological significance of silymarin
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …
[HTML][HTML] Formulation of nanomicelles to improve the solubility and the oral absorption of silymarin
Two novel nanomicellar formulations were developed to improve the poor aqueous
solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and …
solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and …
Silymarin loaded nanostructured lipid carrier: From design and dermatokinetic study to mechanistic analysis of epidermal drug deposition enhancement
This investigation aimed to develop nanostructured lipid carrier (NLC) gel of silymarin for
epidermal tissue deposition enhancement. Binary mixture of solid lipid and liquid lipid was …
epidermal tissue deposition enhancement. Binary mixture of solid lipid and liquid lipid was …
[HTML][HTML] Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation
B Zhang, B Wang, S Cao… - … Journal of Molecular …, 2017 - spandidos-publications.com
Silybin is one of the main flavonoids produced by milk thistle, which has been used in the
treatment of liver diseases. In this study, we examined the protective effects and possible …
treatment of liver diseases. In this study, we examined the protective effects and possible …
[HTML][HTML] Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related
deaths in the US. Cancer-associated cachexia is present in up to 80% of PDAC patients and …
deaths in the US. Cancer-associated cachexia is present in up to 80% of PDAC patients and …
Silymarin and its role in chronic diseases
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25
containing flavonolignan. Milk thistle has a lot of traditional values, being used as a …
containing flavonolignan. Milk thistle has a lot of traditional values, being used as a …
[HTML][HTML] Protective effects of silibinin on Helicobacter pylori-induced gastritis: NF-κB and STAT3 as potential targets
K Cho, HG Lee, JY Piao, SJ Kim, HK Na… - Journal of cancer …, 2021 - ncbi.nlm.nih.gov
More than half of the world's populations are considered to be infected by Helicobacter
pylori. It causes a chronic inflammation of the stomach, which is implicated in the …
pylori. It causes a chronic inflammation of the stomach, which is implicated in the …