The transcription factor MYB has a key role as a regulator of stem and progenitor cells in the
bone marrow, colonic crypts and a neurogenic region of the adult brain. It is in these …

The medicinal use of aspirin stretches back to ancient times, before it was manufactured in
its pure form in the late 19th century. Its accepted mechanistic target, cyclooxygenase (COX) …

Background Patients generally die of cancer after the failure of current therapies to eliminate
residual disease. A subpopulation of tumor cells, termed cancer stem cells (CSC), appears …

Determinants of differentiation and apoptosis in myelomonocytic leukemia cells (U937)
exposed to the novel hybrid polar compound SAHA (suberoylanilide hydroxamic acid) have …

Precise control of hematopoietic stem cell (HSC) proliferation and differentiation is needed
to maintain a lifetime supply of blood cells. Using genome-wide ENU mutagenesis and …

Human plasma membrane-associated sialidase (Neu3) is unique in specifically hydrolyzing
gangliosides, thought to participate in cell differentiation and transmembrane signaling …

The aim of this study was twofold: to assess the relationship between c-Myb and Bcl-x
expression and to evaluate the prognostic significance of their expression in colorectal …

A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor
regulates the expression of hundreds of genes and is in turn regulated by numerous …

c-Myb is a transcription factor employed in the haematopoietic system and gastrointestinal
tract to regulate the exquisite balance between cell division, differentiation and survival. In its …

Peroxisome-proliferator activated receptor-gamma (PPARγ) has been demonstrated to exert
an inhibitory effect on cell growth in most cell types studied, but its role in colon cancer is still …