Although a large number of drugs are available for the treatment of type 2 diabetes mellitus
(T2DM), many patients do not achieve adequate disease control despite adhering to …

Abstract Fibroblast growth factor 21 (FGF21) is a peptide hormone mainly synthesized and
released from the liver. FGF21 acts on FGF21 receptors (FGFRs) and β-Klotho, which is a …

Increased expression of AP-1 transcription factor components has been reported in acute
kidney injury (AKI). However, the role of specific components, such as Fosl1, in tubular cells …

Abstract Sodium-glucose co-transporter-2 inhibitors (SGLT2i) provide cardiorenal protection.
However, the molecular mechanisms remain poorly understood. We explored the impact of …

Objective To understand the mechanisms involved in the response to a low‐K+ diet (LK), we
investigated the role of the growth factor GDF15 and the ion pump H, K‐ATPase type 2 …

Multiple mechanisms are involved in kidney damage, among which the role of epigenetic
modifications in the occurrence and development of kidney diseases is constantly being …

Obesity is strongly associated with the development of diabetes mellitus and chronic kidney
disease (CKD), but there is evidence for a bidirectional relationship wherein the kidney also …

Podocyte inflammatory injury has been indicated to play a pivotal role in the occurrence and
development of diabetic nephropathy (DN). However, the pathogenesis of inflammation …

The inflammatory response is a major pathological feature in most kidney diseases and
often evokes compensatory mechanisms. Recent evidence suggests that TSG-6 (tumor …

Background Chronic kidney disease (CKD), especially diabetic CKD, is the condition that
most increases the risk of lethal coronavirus disease 2019 (COVID-19) caused by severe …