Revolutionizing the early detection of Alzheimer's disease through non-invasive biomarkers: the role of artificial intelligence and deep learning

AG Vrahatis, K Skolariki, MG Krokidis, K Lazaros… - Sensors, 2023 - mdpi.com
Alzheimer's disease (AD) is now classified as a silent pandemic due to concerning current
statistics and future predictions. Despite this, no effective treatment or accurate diagnosis …

Recent advances on electrochemical biosensing strategies toward universal point‐of‐care systems

Y Dai, CC Liu - Angewandte Chemie, 2019 - Wiley Online Library
A number of very recently developed electrochemical biosensing strategies are promoting
electrochemical biosensing systems into practical point‐of‐care applications. The focus of …

CRISPR/Cas12a-mediated interfacial cleaving of hairpin DNA reporter for electrochemical nucleic acid sensing

D Zhang, Y Yan, H Que, T Yang, X Cheng, S Ding… - ACS …, 2020 - ACS Publications
A rapid and sensitive isothermal method is crucial for point-of-care (POC) nucleic acid
testing. Recently, RNA-guided CRISPR/Cas12a proteins were discovered to exhibit target …

A CRISPR/Cas12a-mediated dual-mode electrochemical biosensor for polymerase chain reaction-free detection of genetically modified soybean

H Ge, X Wang, J Xu, H Lin, H Zhou, T Hao… - Analytical …, 2021 - ACS Publications
A clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a-mediated
dual-mode electrochemical biosensor without polymerase chain reaction (PCR) …

[HTML][HTML] Biosensors as diagnostic tools in clinical applications

C Lino, S Barrias, R Chaves, F Adega… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Nowadays, the development of new technological solutions in the medical field, in particular
biosensors, is a priority and a ground for great scientific and financial investment. From …

Applications of biosensors in Alzheimer's disease diagnosis

LC Brazaca, I Sampaio, V Zucolotto, BC Janegitz - Talanta, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
and irreversible cognitive decline. Currently, it affects 36 million people and due to …

Electrochemical immunosensors developed for amyloid-beta and tau proteins, leading biomarkers of Alzheimer's disease

A Sharma, L Angnes, N Sattarahmady, M Negahdary… - Biosensors, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurological disease and a serious cause of
dementia, which constitutes a threat to human health. The clinical evidence has found that …

Charge-dependent signal changes for label-free electrochemiluminescence immunoassays

D Du, J Wang, M Guo, J Shu, W Nie, Z Bian… - Analytical …, 2022 - ACS Publications
Label-free electrochemiluminescence (ECL) immunoassays (lf-ECLIA), based on biomarker-
induced ECL signal changes, have attracted increasing attention due to the simple, rapid …

Electrochemical aptasensor for Staphylococcus aureus by stepwise signal amplification

H Zhou, W Guo, S Wang, T Hao, Z Wang, Y Hu… - Microchimica Acta, 2022 - Springer
An electrochemical aptasensor for ultrasensitive detection of Staphylococcus aureus (SA)
has been developed based on stepwise signal amplification. In the sample processing …

Strand displacement strategies for biosensor applications

Y Dai, A Furst, CC Liu - Trends in biotechnology, 2019 - cell.com
DNA has many unique properties beyond encoding genetic information, one of which is its
physicochemical stability based on Watson–Crick base pairing. Differences in sequence …