Embryo–epithelium interactions during implantation at a glance

JD Aplin, PT Ruane - Journal of cell science, 2017 - journals.biologists.com
At implantation, with the acquisition of a receptive phenotype in the uterine epithelium, an
initial tenuous attachment of embryonic trophectoderm initiates reorganisation of epithelial …

Uterine luminal epithelium as the transient gateway for embryo implantation

X Ye - Trends in Endocrinology & Metabolism, 2020 - cell.com
The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo.
Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural …

Alterations in epithelial cell polarity during endometrial receptivity: a systematic review

S Whitby, W Zhou, E Dimitriadis - Frontiers in Endocrinology, 2020 - frontiersin.org
Background Abnormal endometrial receptivity is one of the major causes of embryo
implantation failure and infertility. The plasma membrane transformation (PMT) describes …

[HTML][HTML] The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42

Z Zhu, Z Yu, Z Rong, Z Luo, J Zhang, Z Qiu… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: As a component of GINS complex, GINS4 is essential for initiating DNA
replication and elongation of the cell cycle G1/S phase in eukaryotes and plays a vital role in …

Evolutionary divergence of embryo implantation in primates

D Siriwardena, TE Boroviak - … Transactions of the …, 2022 - royalsocietypublishing.org
Implantation of the conceptus into the uterus is absolutely essential for successful embryo
development. In humans, our understanding of this process has remained rudimentary …

The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

X Ma, X Ma, L Zhu, Y Zhao, M Chen, T Li, Y Lin, D Ma… - Oncogenesis, 2022 - nature.com
Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are
correlated with aggressive growth and other malignant characteristics in a wide variety of …

Mechanisms controlling germline cyst breakdown and primordial follicle formation

C Wang, B Zhou, G Xia - Cellular and Molecular Life Sciences, 2017 - Springer
In fetal females, oogonia proliferate immediately after sex determination. The progress of
mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister …

[HTML][HTML] Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice

C Cheng, Y Hou, Z Zhang, Y Wang, L Lu… - Journal of Genetics and …, 2021 - Elsevier
Several clinical studies have reported that hearing loss is correlated with autism in children.
However, little is known about the underlying mechanism between hearing loss and autism …

Proteome reprogramming of endometrial epithelial cells by human trophectodermal small extracellular vesicles reveals key insights into embryo implantation

QH Poh, A Rai, II Carmichael, LA Salamonsen… - …, 2021 - Wiley Online Library
Embryo implantation into the receptive endometrium is critical in pregnancy establishment,
initially requiring reciprocal signalling between outer layer of the blastocyst (trophectoderm …

Rapid generation of functional nanovesicles from human trophectodermal cells for embryo attachment and outgrowth

QH Poh, A Rai, M Pangestu, LA Salamonsen… - …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth
critical for successful implantation. While EVs have garnered immense interest in their …