ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …

Obesity is caused by a long-term difference between energy intake and expenditure—an
imbalance that is seemingly easily restored by increasing exercise and reducing caloric …

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Mammalian organs are nourished by nutrients carried by the blood circulation. These
nutrients originate from diet and internal stores, and can undergo various interconversions …

The main focus of the International Journal of Obesity (IJO) is to better understand human
obesity. Many scientists use rodents as convenient models to dissect aspects of physiology …

For decades, dietary advice was based on the premise that high intakes of fat cause obesity,
diabetes, heart disease, and possibly cancer. Recently, evidence for the adverse metabolic …

Non-alcoholic fatty liver disease (NAFLD) affects approximately 1 in 4 people worldwide and
is a major burden to health care systems. A major concern in NAFLD research is lack of …

Studies on fat intake and obesity have been inconclusive. This study examined the
associations between dietary fat intake and body weight and the risk of overweight and …

Low-protein diets promote metabolic health in humans and rodents. Despite evidence that
sex and genetic background are key factors in the response to diet, most protein intake …

A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on
their brain health and behavior. During the past three decades, obesity has rapidly …