Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection

MS Cardoso, JL Reis-Cunha… - Frontiers in …, 2016 - frontiersin.org
Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …

Analysis of over 1500 triatomine vectors from across the US, predominantly Texas, for Trypanosoma cruzi infection and discrete typing units

R Curtis-Robles, LD Auckland, KF Snowden… - Infection, Genetics and …, 2018 - Elsevier
Across the Americas, triatomine insects harbor diverse strains of Trypanosoma cruzi (T.
cruzi), agent of Chagas disease. Geographic patterns of vector infection and parasite strain …

Molecular diagnosis of Chagas disease in Colombia: parasitic loads and discrete typing units in patients from acute and chronic phases

C Hernández, Z Cucunubá, C Flórez… - PLoS neglected …, 2016 - journals.plos.org
Background The diagnosis of Chagas disease is complex due to the dynamics of
parasitemia in the clinical phases of the disease. The molecular tests have been considered …

[HTML][HTML] Evidence and importance of genetic exchange among field populations of Trypanosoma cruzi

LA Messenger, MA Miles - Acta Tropica, 2015 - Elsevier
Many eukaryotic pathogenic microorganisms that were previously assumed to propagate
clonally have retained cryptic sexual cycles. The principal reproductive mode of …

Untangling the transmission dynamics of primary and secondary vectors of Trypanosoma cruzi in Colombia: parasite infection, feeding sources and discrete typing …

C Hernández, C Salazar, H Brochero, A Teherán… - Parasites & …, 2016 - Springer
Background Trypanosoma cruzi is the causative agent of Chagas disease. Due to its genetic
diversity has been classified into six Discrete Typing Units (DTUs) in association with …

The diversity of the Chagas parasite, Trypanosoma cruzi, infecting the main Central American vector, Triatoma dimidiata, from Mexico to Colombia

PL Dorn, AG McClure, MD Gallaspy… - PloS neglected …, 2017 - journals.plos.org
Little is known about the strains of Trypanosoma cruzi circulating in Central America and
specifically in the most important vector in this region, Triatoma dimidiata. Approximately six …

A systematic review of the Trypanosoma cruzi genetic heterogeneity, host immune response and genetic factors as plausible drivers of chronic chagasic …

P Jiménez, J Jaimes, C Poveda, JD Ramírez - Parasitology, 2019 - cambridge.org
Chagas disease is a complex tropical pathology caused by the kinetoplastid Trypanosoma
cruzi. This parasite displays massive genetic diversity and has been classified by …