RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …

Ribozymes can catalyze a large variety of different reactions, but very few mechanistic
aspects are understood in detail. 1-9 It is evident that RNAs are always associated with …

Many recently discovered noncoding RNAs do not fold into a single native conformation but
sample many different conformations along their free-energy landscape to carry out their …

ABSTRACT pH is a ubiquitous regulator of biological activity, including protein‐folding,
protein‐protein interactions, and enzymatic activity. Existing constant pH molecular …

The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in
eukaryotes, contains over 200 different proteins and five RNA molecules. The central role …

pKa calculations based on the Poisson–Boltzmann equation have been widely used to
study proteins and, more recently, DNA. However, much less attention has been paid to the …

Proper functioning of RNAs requires the formation of complex three‐dimensional structures
combined with the ability to rapidly interconvert between multiple functional states. This …

Group II introns are ubiquitous self-splicing ribozymes and retrotransposable elements
evolutionarily and chemically related to the eukaryotic spliceosome, with potential …

The application of real‐time NMR experiments to the study of RNA folding, as reviewed in
this article, is relatively new. For many RNA folding events, current investigations suggest …

An increasing number of RNAs are being discovered that perform their functions by
undergoing large changes in conformation in response to a variety of cellular signals …