Mechanisms of photosensitized lipid oxidation and membrane permeabilization

IOL Bacellar, MS Baptista - Acs Omega, 2019 - ACS Publications
Lipid oxidation encompasses chemical transformations affecting animals and plants in many
ways, and light is one of the most common triggers of lipid oxidation in our habitat. Still, the …

Photosensitized membrane permeabilization requires contact-dependent reactions between photosensitizer and lipids

IOL Bacellar, MC Oliveira, LS Dantas… - Journal of the …, 2018 - ACS Publications
Although the general mechanisms of lipid oxidation are known, the chemical steps through
which photosensitizers and light permeabilize lipid membranes are still poorly understood …

Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers

KA Runas, N Malmstadt - Soft matter, 2015 - pubs.rsc.org
Oxidation of unsaturated lipids in cellular membranes has been shown to cause severe
membrane damage and potentially cell death. The presence of oxidized lipid species in the …

Membrane changes under oxidative stress: the impact of oxidized lipids

R Itri, HC Junqueira, O Mertins, MS Baptista - Biophysical reviews, 2014 - Springer
Studying photosensitized oxidation of unsaturated phospholipids is of importance for
understanding the basic processes underlying photodynamic therapy, photoaging and many …

Enhanced efficiency of cell death by lysosome-specific photodamage

TM Tsubone, WK Martins, C Pavani, HC Junqueira… - Scientific reports, 2017 - nature.com
Mobilization of specific mechanisms of regulated cell death is a promising alternative to treat
challenging illness such as neurodegenerative disease and cancer. The use of light to …

Directly imaging emergence of phase separation in peroxidized lipid membranes

M Paez-Perez, A Vyšniauskas, I López-Duarte… - Communications …, 2023 - nature.com
Lipid peroxidation is a process which is key in cell signaling and disease, it is exploited in
cancer therapy in the form of photodynamic therapy. The appearance of hydrophilic moieties …

Antioxidant properties of ergosterol and its role in yeast resistance to oxidation

S Dupont, P Fleurat-Lessard, RG Cruz, C Lafarge… - Antioxidants, 2021 - mdpi.com
Although the functions and structural roles of sterols have been the subject of numerous
studies, the reasons for the diversity of sterols in the different eukaryotic kingdoms remain …

Understanding membrane remodelling initiated by photosensitized lipid oxidation

TM Tsubone, MS Baptista, R Itri - Biophysical chemistry, 2019 - Elsevier
In this review, we describe how photooxidation changes membrane properties that can
ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the …

[HTML][HTML] Contrasting roles of oxidized lipids in modulating membrane microdomains

TM Tsubone, HC Junqueira, MS Baptista… - Biochimica et Biophysica …, 2019 - Elsevier
Lipid rafts display a lateral heterogeneity forming membrane microdomains that hold a
fundamental role on biological membranes and are indispensable to physiological functions …

[HTML][HTML] The dynamics of giant unilamellar vesicle oxidation probed by morphological transitions

S Sankhagowit, SH Wu, R Biswas, CT Riche… - … et Biophysica Acta (BBA …, 2014 - Elsevier
We have studied the dynamics of Lissamine Rhodamine B dye sensitization-induced
oxidation of 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) giant unilamellar vesicles …