It is now plausible to dock libraries of 10 million molecules against targets over several days
or weeks. When the molecules screened are commercially available, they may be rapidly …

Major goal of structural biology involve formation of protein-ligand complexes; in which the
protein molecules act energetically in the course of binding. Therefore, perceptive of protein …

The radical SAM superfamily contains over 100,000 homologous enzymes that catalyze a
remarkably broad range of reactions required for life, including metabolism, nucleic acid …

Abstract In the Ninth Edition of the Critical Assessment of Techniques for Protein Structure
Prediction (CASP9), 61,665 models submitted by 176 groups were assessed for their …

The Enzyme Function Initiative (EFI) was recently established to address the challenge of
assigning reliable functions to enzymes discovered in bacterial genome projects; in this …

Nature's strategies for evolving catalytic functions can be deciphered from the information
contained in the rapidly expanding protein sequence databases. However, the functions of …

Two orders of magnitude more protein sequences can be modeled by comparative
modeling than have been determined by X-ray crystallography and NMR spectroscopy …

We describe the proceedings and conclusions from the" Workshop on Applications of
Protein Models in Biomedical Research"(the Workshop) that was held at the University of …

Solute Carrier (SLC) transporters are membrane proteins that transport solutes, such as
ions, metabolites, peptides, and drugs, across biological membranes, using diverse energy …

Biocatalysis has emerged as an important alternative to traditional chemical synthesis for the
preparation of fine chemicals,[1] as recently demonstrated by the biocatalytic manufacture of …