Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of
genomic loci. Recent work suggested that rather than up-and downregulating selected …

Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …

In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …

Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to
ionizing radiation. The repair of DSBs involves both posttranslational modification of …