Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant
solid tumors. CM is characterized by a remarkable metabolic plasticity and an important …

Nitroxides are stable free radicals that contain a nitroxyl group with an unpaired electron. In
this paper, we present the properties and application of nitroxides as antioxidants and …

Oxidative stress nearly always accompanies all stages of cancer development. At the early
stages, antioxidants may help to reduce reactive oxygen species (ROS) production and …

We previously reported that upregulation of mortalin (HSPA9/GRP75), the mitochondrial
HSP70 chaperone, facilitates tumor cell proliferation and survival in human medullary …

Background Besides its influence on survival, growth, proliferation, invasion and metastasis,
cancer cell metabolism also greatly influences the cellular responses to molecular-targeted …

The tumor microenvironment affects the structure and metabolic function of mitochondria in
tumor cells. This process involves changes in metabolic activity, an increase in the amount …

Mitochondrial dysfunction (MDF) has been identified as an important factor in various
diseases ranging from neurological disorders, to diseases of the cardiovascular system and …