Metformin and insulin resistance: a review of the underlying mechanisms behind changes in GLUT4-mediated glucose transport

R Herman, NA Kravos, M Jensterle, A Janež… - International journal of …, 2022 - mdpi.com
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-
resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and …

[HTML][HTML] Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

JW Singer, A Fleischman, S Al-Fayoumi… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Abstract Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and
IRAK4) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling …

Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients

J Sabbatinelli, A Giuliani, G Matacchione… - Mechanisms of ageing …, 2021 - Elsevier
Current COVID-19 pandemic poses an unprecedented threat to global health and
healthcare systems. The most amount of the death toll is accounted by old people affected …

NurOwn, phase 2, randomized, clinical trial in patients with ALS: safety, clinical, and biomarker results

JD Berry, ME Cudkowicz, AJ Windebank, NP Staff… - Neurology, 2019 - AAN Enterprises
Objective To determine the safety and efficacy of mesenchymal stem cell (MSC)-
neurotrophic factor (NTF) cells (NurOwn®, autologous bone marrow-derived MSCs, induced …

Circulating microRNA-122, microRNA-126-3p and microRNA-146a are associated with inflammation in patients with pre-diabetes and type 2 diabetes mellitus: A case …

F Zeinali, SM Aghaei Zarch, A Jahan-Mihan… - PloS one, 2021 - journals.plos.org
The prevalence of type 2 diabetes mellitus (T2DM) is increasing dramatically worldwide.
Dysregulation of microRNA (miRNA) as key regulators of gene expression, has been …

Exosomal microRNA‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K …

L Qiu, J Wang, M Chen, F Chen… - … journal of molecular …, 2020 - spandidos-publications.com
The carrier role of exosomes from human umbilical cord mesenchymal stem cells
(hUCMSCs) containing microRNAs (miRNAs) has been implicated in gene and drug …

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

K Ait-Aissa, QM Nguyen, M Gabani, A Kassan… - Cardiovascular …, 2020 - Springer
The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global
epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity …

Analysis of novel immunological biomarkers related to rheumatoid arthritis disease severity

S Pascual-García, P Martínez-Peinado… - International Journal of …, 2023 - mdpi.com
Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) are the most
frequently used rheumatoid arthritis (RA) diagnostic markers, but they are unable to …

20 Years with SGBS cells-a versatile in vitro model of human adipocyte biology

D Tews, RE Brenner, R Siebert, KM Debatin… - International Journal of …, 2022 - nature.com
Abstract 20 years ago, we described a human cell strain derived from subcutaneous
adipose tissue of an infant supposed to have Simpson-Golabi-Behmel Syndrome (SGBS) …

Anti-inflammatory effects of mesenchymal stem cell-derived exosomal microRNA-146a-5p and microRNA-548e-5p on human trophoblast cells

C Yang, W Lim, J Park, S Park, S You… - Molecular human …, 2019 - academic.oup.com
Human umbilical cord mesenchymal stem cells (MSCs) have been reported to improve the
migration and invasion of trophoblast cells; however, little is known about whether MSC …