Abstract Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has
become a key challenge to study their structure, their molecular and cellular functions and …

Stroke is the second-leading cause of death worldwide, yet there are no drugs available to
protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) …

Oncotic cell death or oncosis represents a major mechanism of cell death in ischaemic
stroke, occurring in many central nervous system (CNS) cell types including neurons, glia …

Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in mammalian brain and
plays a major role in neuronal injury following cerebral ischemia. Evidence that inhibition of …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates redox
homeostasis of the cell through regulation of the antioxidant response element genes …

Background Even though more than 600 stroke treatments have been shown effective in
preclinical studies, clinically proven treatment alternatives for cerebral infarction remain …

The pathophysiology of stroke is characterized by biochemical and physical alterations in
the brain. Modulation of such aberrations by therapeutic agents affords insights into their …

R‐flurbiprofen is the non‐cyclooxygenase inhibiting R‐enantiomer of the non‐steroidal anti‐
inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease …

Objectives Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely
used in the treatment of inflammation and pain. Most effects of NSAIDs are attributed to the …

Hi1a is a venom peptide from the Australian funnel-web spider Hadronyche infensa with a
complex tertiary structure. Hi1a has neuroprotective and cardioprotective properties due to …