SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain
without evident clinical symptoms. Once in the central nervous system (CNS), the virus can …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor
necrosis factor family mediate this process. They either assist persistent viral infection or …

Viruses are ubiquitous intracellular genetic parasites that heavily rely on the infected cell to
complete their replication life cycle. This dependency on the host machinery forces viruses …

In response to invasion by microbial pathogens, host defense mechanisms get activated by
both the innate and adaptive arms of the immune responses. TNF (tumor necrosis factor) is a …

ABSTRACT A number of sentinels sense incoming herpes simplex virus (HSV) virions and
initiate an immediate innate response. The first line of defense at the cell surface is TLR2 …

The discovery of the Toll-like receptors (TLRs) and their importance in the regulation of host
responses to infection raised attention to the complex interplay between viral gene products …

Pattern recognition receptors represent the first line of defense against invading pathogens.
Herpes simplex virus (HSV) encodes multiple ligands detected by these receptors, yet …

Apoptosis, an important innate immune mechanism that eliminates pathogen-infected cells,
is primarily triggered by two signalling pathways: the death receptor pathway and the …