Pharmaceutical compounds such antibiotics, anti-inflammatories, psychotropics, human
drugs, hormones, anticonvulsants, antidepressants, veterinary drugs and steroids occur …

Near infrared (NIR) spectroscopy has been widely recognized as a powerful PAT tool for
monitoring blend uniformity in continuous manufacturing (CM) processes. However, the …

Near-infrared spectroscopy (NIRS) is nowadays an established analytical technique in the
pharmaceutical industry. The aim of this review is to present the progress of NIRS in …

Oral solid dosage forms, the most widely used pharmaceutical products, are typically
manufactured through a series of processes that transform a blend of drug and excipient …

In-line measurements of low dose blends in the feed frame of a tablet press were performed
for API concentration levels as low as 0.10% w/w. The proposed methodology utilizes the …

The feed frame is a force-feeding device used in the die filling process. The die filling
process is crucial within pharmaceutical manufacturing to guarantee the critical quality …

The presence of a 'significant dead zone'in any continuous manufacturing equipment may
affect the product quality and need to be investigated systematically. Dead zone will affect …

The influence of different tableting process parameters on lead-lag was studied by collecting
in-line near-infrared (NIR) spectra in the filling chamber of the tablet press feed frame and off …

Near-infrared (NIR) spectroscopy is one of the most successful pharmaceutical process
analytical tools. For botanical drug products (BDPs), many studies have applied NIR …

This work describes the characterization of three NIR interfaces intended to monitor a
continuous granulation process. Two interfaces (ie a barrel interface and a rotating paddle …