[HTML][HTML] The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer

W Ashraf, A Ibrahim, M Alhosin, L Zaayter… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cancer is one of the deadliest diseases in the world causing record number of mortalities in
both developed and undeveloped countries. Despite a lot of advances and breakthroughs in …

Classification of thyroid follicular cell tumors: with special reference to borderline lesions

K Kakudo, Y Bai, Z Liu, Y Li, Y Ito, T Ozaki - Endocrine journal, 2012 - jstage.jst.go.jp
We propose a new classification of thyroid follicular cell tumors which is correlated with
patient's prognosis. It is unique as to two new categories: borderline malignancy between …

Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione

MW O'Reilly, AE Taylor, NJ Crabtree… - The journal of …, 2014 - academic.oup.com
Background: Anaplastic thyroid carcinomas (ATCs) are among the most lethal malignancies,
for which there is no effective treatment. Objective: In the present study, we aimed to …

UHRF1 is a novel diagnostic marker of lung cancer

M Unoki, Y Daigo, J Koinuma, E Tsuchiya… - British journal of …, 2010 - nature.com
Background: Lung cancer is the leading cause of cancer deaths worldwide. As the sensitivity
and specificity of current diagnostic markers are not perfect, we examined whether ubiquitin …

Cancer-associated fibroblasts positively correlate with dedifferentiation and aggressiveness of thyroid cancer

S Wen, N Qu, B Ma, X Wang, Y Luo, W Xu… - OncoTargets and …, 2021 - Taylor & Francis
Background and Objectives Targeting cancer-associated fibroblast (CAF) is being explored
as an approach to improve cancer therapies. The roles of CAF remain unclarified in …

Cell Cycle Deregulation and TP53 and RAS Mutations Are Major Events in Poorly Differentiated and Undifferentiated Thyroid Carcinomas

JM Pita, IF Figueiredo, MM Moura… - The Journal of …, 2014 - academic.oup.com
Background: Anaplastic thyroid carcinomas (ATCs) are among the most lethal malignancies,
for which there is no effective treatment. Objective: In the present study, we aimed to …

Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

A Abusnina, T Keravis, I Yougbaré… - Molecular nutrition & …, 2011 - Wiley Online Library
Scope: Curcumin inhibits proliferation of many cancer cells. Cyclic nucleotide
phosphodiesterases (PDEs), by hydrolyzing intracellular cyclic adenosine‐3′, 5 …

The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer

C Colombo, E Minna, C Gargiuli, M Muzza… - Journal of Experimental …, 2020 - Springer
Background Papillary thyroid cancer (PTC) is the most frequent endocrine tumor.
Radioiodine (RAI) treatment is highly effective in these tumors, but up to 60% of metastatic …

Stratification of follicular thyroid tumours using data‐independent acquisition proteomics and a comprehensive thyroid tissue spectral library

Y Sun, L Li, Y Zhou, W Ge, H Wang, R Wu… - Molecular …, 2022 - Wiley Online Library
Thyroid nodules occur in about 60% of the population. A major challenge in thyroid nodule
diagnosis is to distinguish between follicular adenoma (FA) and carcinoma (FTC). Here, we …

Cancer associated fibroblasts and senescent thyroid cells in the invasive front of thyroid carcinoma

E Minna, S Brich, K Todoerti, S Pilotti, P Collini… - Cancers, 2020 - mdpi.com
Thyroid carcinoma (TC) comprises several histotypes with different aggressiveness, from
well (papillary carcinoma, PTC) to less differentiated forms (poorly differentiated and …