Probing neural codes with two-photon holographic optogenetics
H Adesnik, L Abdeladim - Nature neuroscience, 2021 - nature.com
Optogenetics ushered in a revolution in how neuroscientists interrogate brain function.
Because of technical limitations, the majority of optogenetic studies have used low spatial …
Because of technical limitations, the majority of optogenetic studies have used low spatial …
Molecular fluorophores for deep-tissue bioimaging
Fluorescence imaging has made tremendous inroads toward understanding the complexity
of biological systems, but in vivo deep-tissue imaging remains a great challenge due to the …
of biological systems, but in vivo deep-tissue imaging remains a great challenge due to the …
High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy
Two-photon microscopy has enabled high-resolution imaging of neuroactivity at depth within
scattering brain tissue. However, its various realizations have not overcome the tradeoffs …
scattering brain tissue. However, its various realizations have not overcome the tradeoffs …
An expanded palette of dopamine sensors for multiplex imaging in vivo
Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …
Fluorescence imaging of large-scale neural ensemble dynamics
TH Kim, MJ Schnitzer - Cell, 2022 - cell.com
Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …
thousands of individual neurons, identified genetically or by their connectivity, across …
High-speed multiplane confocal microscopy for voltage imaging in densely labeled neuronal populations
Genetically encoded voltage indicators (GEVIs) hold immense potential for monitoring
neuronal population activity. To date, best-in-class GEVIs rely on one-photon excitation …
neuronal population activity. To date, best-in-class GEVIs rely on one-photon excitation …
Imaging neurotransmitter and neuromodulator dynamics in vivo with genetically encoded indicators
BL Sabatini, L Tian - Neuron, 2020 - cell.com
The actions of neuromodulation are thought to mediate the ability of the mammalian brain to
dynamically adjust its functional state in response to changes in the environment. Altered …
dynamically adjust its functional state in response to changes in the environment. Altered …
Illuminating dendritic function with computational models
P Poirazi, A Papoutsi - Nature reviews neuroscience, 2020 - nature.com
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
to the beautiful recordings of today, neuroscientists have been striving to unravel the …
Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission
The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with
genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo …
genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo …
Imaging volumetric dynamics at high speed in mouse and zebrafish brain with confocal light field microscopy
Z Zhang, L Bai, L Cong, P Yu, T Zhang, W Shi… - Nature …, 2021 - nature.com
A detailed understanding of the function of neural networks and how they are supported by a
dynamic vascular system requires fast three-dimensional imaging in thick tissues. Here we …
dynamic vascular system requires fast three-dimensional imaging in thick tissues. Here we …