Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

A 39-year-old female executive has a several-month history of fatigue, headache, and
memory lapse. During a period of feeling worse than usual, she called a friend, who arrived …

▪ Abstract Many biological functions of heme oxygenase (HO), such as cytoprotection
against oxidative stress, vasodilation, neurotransmission in the central or peripheral nervous …

Heme oxygenase-1 (HO-1), a ubiquitous inducible stress-response protein, serves a major
metabolic function in heme turnover. HO activity cleaves heme to form biliverdin-IXα, carbon …

Heme oxygenase (HO) has been shown to be important for attenuating the overall
production of reactive oxygen species (ROS) through its ability to degrade heme and to …