lncRNAs and microRNAs with a role in cancer development
J Liz, M Esteller - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2016 - Elsevier
Most diseases, including human cancer, are frequently associated with an altered
transcription pattern. The alteration of the transcriptome is not restricted to the production of …
transcription pattern. The alteration of the transcriptome is not restricted to the production of …
Insights into RNA structure and function from genome-wide studies
SA Mortimer, MA Kidwell, JA Doudna - Nature Reviews Genetics, 2014 - nature.com
A comprehensive understanding of RNA structure will provide fundamental insights into the
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
[HTML][HTML] Pervasive downstream RNA hairpins dynamically dictate start-codon selection
Translational reprogramming allows organisms to adapt to changing conditions. Upstream
start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in …
start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in …
rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
CK Kwok, G Marsico, AB Sahakyan, VS Chambers… - Nature …, 2016 - nature.com
We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-
quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling …
quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling …
Characterization of stress‐responsive lncRNAs in Arabidopsis thaliana by integrating expression, epigenetic and structural features
Recently, in addition to poly (A)+ long non‐coding RNA s (lnc RNA s), many lnc RNA s
without poly (A) tails, have been characterized in mammals. However, the non‐polyA lnc …
without poly (A) tails, have been characterized in mammals. However, the non‐polyA lnc …
High-throughput determination of RNA structures
RNA performs and regulates a diverse range of cellular processes, with new functional roles
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
COMRADES determines in vivo RNA structures and interactions
The structural flexibility of RNA underlies fundamental biological processes, but there are no
methods for exploring the multiple conformations adopted by RNAs in vivo. We developed …
methods for exploring the multiple conformations adopted by RNAs in vivo. We developed …
Accurate detection of chemical modifications in RNA by mutational profiling (MaP) with ShapeMapper 2
S Busan, KM Weeks - Rna, 2018 - rnajournal.cshlp.org
Mutational profiling (MaP) enables detection of sites of chemical modification in RNA as
sequence changes during reverse transcription (RT), subsequently read out by massively …
sequence changes during reverse transcription (RT), subsequently read out by massively …
RNA G-quadruplex structures exist and function in vivo in plants
Background Guanine-rich sequences are able to form complex RNA structures termed RNA
G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed …
G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed …
hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1
The structure of messenger RNA is important for post-transcriptional regulation, mainly
because it affects binding of trans-acting factors. However, little is known about the in vivo …
because it affects binding of trans-acting factors. However, little is known about the in vivo …