Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …

α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters
from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of …

Objective To study the feasibility of plasma extracellular vesicles (EVs) miRNAs as
diagnostic biomarkers for Parkinson's disease (PD). Methods Plasma EVs were isolated …

The development of disease-modifying drugs and differential diagnostic agents is an urgent
medical need in Parkinson's disease. Despite the complex pathophysiological pathway, the …

Liquid–liquid phase separation (LLPS) appears to be a newly appreciated aspect of the
cellular organization of biomolecules that leads to the formation of membraneless …

Despite being a major component of Lewy bodies and Lewy neurites, pathogenic variants in
the gene encoding alpha-Synuclein (α-Syn) are rare. To date, only four missense variants in …

Background: Earlier studies reported alterations of the kynurenine (KYN) pathway of
tryptophan (TRP) metabolism in Parkinson's disease (PD). The first rate-limiting enzymes …

Amyloid protein aggregates are linked to the progression of neurodegenerative conditions
and may play a role in life stages of Plasmodium falciparum, the parasite responsible for …

Mitochondria play a primary role in the pathophysiology of Parkinson's disease (PD), and
small molecules that counteract the initial stages of disease may offer therapeutic benefit. In …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the
degeneration of dopaminergic neurons in the substantia nigra (SN); the etiology and …