2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the …

K Zeppenfeld, J Tfelt-Hansen, M De Riva… - European heart …, 2022 - academic.oup.com
4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030

B Vogel, M Acevedo, Y Appelman, CNB Merz… - The Lancet, 2021 - thelancet.com
Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …

Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association

MCP Nunes, A Beaton, H Acquatella, C Bern… - Circulation, 2018 - Am Heart Assoc
Background: Chagas disease, resulting from the protozoan Trypanosoma cruzi, is an
important cause of heart failure, stroke, arrhythmia, and sudden death. Traditionally …

Randomized trial of benznidazole for chronic Chagas' cardiomyopathy

CA Morillo, JA Marin-Neto, A Avezum… - … England Journal of …, 2015 - Mass Medical Soc
Background The role of trypanocidal therapy in patients with established Chagas'
cardiomyopathy is unproven. Methods We conducted a prospective, multicenter …

The bowel and beyond: the enteric nervous system in neurological disorders

M Rao, MD Gershon - Nature reviews Gastroenterology & hepatology, 2016 - nature.com
The enteric nervous system (ENS) is large, complex and uniquely able to orchestrate
gastrointestinal behaviour independently of the central nervous system (CNS). An intact …

Chagas disease in the United States: a public health approach

C Bern, LA Messenger, JD Whitman… - Clinical microbiology …, 2019 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by
triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal …

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

MC Field, D Horn, AH Fairlamb… - Nature Reviews …, 2017 - nature.com
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

II Consenso Brasileiro em doença de Chagas, 2015

JCP Dias, AN Ramos Jr, ED Gontijo… - … e Serviços de …, 2016 - SciELO Public Health
RESUMO A doença de Chagas é uma condição crônica negligenciada com elevada carga
de morbimortalidade e impacto dos pontos de vista psicológico, social e econômico …

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

S Khare, AS Nagle, A Biggart, YH Lai, F Liang… - Nature, 2016 - nature.com
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide
and lead to more than 50,000 deaths annually. The diseases are caused by infection with …