Ferroptosis and its potential role in the physiopathology of Parkinson's Disease

L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

The role of oxidative stress in Parkinson's disease

V Dias, E Junn, MM Mouradian - Journal of Parkinson's …, 2013 - content.iospress.com
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

B Do Van, F Gouel, A Jonneaux, K Timmerman… - Neurobiology of …, 2016 - Elsevier
Parkinson's disease (PD) is a complex illness characterized by progressive dopaminergic
neuronal loss. Several mechanisms associated with the iron-induced death of dopaminergic …

Mitochondrial DNA damage triggers spread of Parkinson's disease-like pathology

E Tresse, J Marturia-Navarro, WQG Sew… - Molecular …, 2023 - nature.com
In the field of neurodegenerative diseases, especially sporadic Parkinson's disease (sPD)
with dementia (sPDD), the question of how the disease starts and spreads in the brain …

Glutathione metabolism and Parkinson's disease

M Smeyne, RJ Smeyne - Free Radical Biology and Medicine, 2013 - Elsevier
It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

LH Sanders, JT Greenamyre - Free Radical Biology and Medicine, 2013 - Elsevier
Parkinson disease (PD), the most common neurodegenerative movement disorder, is
associated with selective degeneration of nigrostriatal dopamine neurons. Although the …

The human selenoproteome: recent insights into functions and regulation

MA Reeves, PR Hoffmann - Cellular and molecular life sciences, 2009 - Springer
Selenium (Se) is a nutritional trace mineral essential for various aspects of human health
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …

Therapeutic insights on ferroptosis in Parkinson's disease

K Thapa, H Khan, N Kanojia, TG Singh, A Kaur… - European journal of …, 2022 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder that alters either motor or non-
motor activities. Dopamine-based medications can help alleviate symptoms at an early …

The role of cysteine oxidation in DJ-1 function and dysfunction

MA Wilson - Antioxidants & redox signaling, 2011 - liebertpub.com
DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has
homologs in nearly all organisms. Because of its connection to parkinsonism and cancer …

Selenium and selenoprotein function in brain disorders

R Pillai, JH Uyehara‐Lock, FP Bellinger - IUBMB life, 2014 - Wiley Online Library
Selenoproteins are important for normal brain function, and decreased function of
selenoproteins can lead to impaired cognitive function and neurological disorders. This …