Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …

ATP-hydrolysis-coupled actin polymerization is a fundamental mechanism of cellular force
generation,–. In turn, force, and actin filament (F-actin) nucleotide state regulate actin …

Breast cancer progression features ECM stiffening due to excess deposition and
crosslinking of collagen, which dramatically influence tumor behaviour and fate. The …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …

Stress fibers and focal adhesions are complex protein arrays that produce, transmit and
sense mechanical tension. Evidence accumulated over many years led to the conclusion …

Observation of molecular processes inside living cells is fundamental to a quantitative
understanding of how biological systems function. Specifically, decoding the complex …

Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

Actin filaments assemble into diverse protrusive and contractile structures to provide force
for a number of vital cellular processes. Stress fibers are contractile actomyosin bundles …