Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

Anti-tubulin agent vinorelbine inhibits metastasis of cancer cells by regulating epithelial-mesenchymal transition

H Liu, Q Fu, Y Lu, W Zhang, P Yu, Z Liu… - European Journal of …, 2020 - Elsevier
Cancer invasion and metastasis are the leading causes of death. The process of metastasis
or tumor cell dissemination is still much of a mystery. Emerging evidence has shown that …

IFN‑γ induces apoptosis in gemcitabine‑resistant pancreatic cancer cells

X Kong, D Cheng, X Xu… - Molecular Medicine …, 2024 - spandidos-publications.com
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent and aggressive form of
pancreatic cancer. Gemcitabine (GEM), the first‑line treatment for PDAC, which alleviates …

[HTML][HTML] Correlation between expression of epidermal growth factor receptor and adverse reactions after chemotherapy of advanced non-small-cell lung cancer

Z Hao, C Tian, F Yang, J Zhang - Pakistan Journal of Medical …, 2015 - ncbi.nlm.nih.gov
Objective: To analyze the correlation between expression of epidermal growth factor
receptor (EGFR) and adverse reactions after chemotherapy of advanced non-small-cell lung …

TRAIL predisposes non-small cell lung cancer to ferroptosis by regulating ASK-1/JNK1 pathway

X Liu, H Deng, M Huang, W Zhou, Y Yang - Discover Oncology, 2024 - Springer
Objective Our current study aimed to assess the relationship between TNF-related apoptosis-
inducing ligand (TRAIL) and ferroptosis in non-small cell lung cancer (NSCLC) …

RNA-Seq and network analysis revealed interacting pathways in TGF-β-treated lung cancer cell lines

Y Li, O Rouhi, H Chen, R Ramirez… - Cancer …, 2014 - journals.sagepub.com
Whole transcriptome shotgun sequencing (RNA-Seq) is a useful tool for analyzing the
transcriptome of a biological sample. With appropriate statistical and bioinformatic …

Tumor necrosis factor-related apoptosis-inducing ligand modulates angiogenesis and apoptosis to inhibit non-small cell lung carcinoma tumor growth in mice

Y Chen, Y Xu, K Zhu, Z Cao… - Journal of International …, 2019 - journals.sagepub.com
Objective To investigate the anti-tumor effect and mechanism of tumor necrosis factor-
related apoptosis-inducing ligand (TRAIL) in non-small cell lung carcinoma (NSCLC) in …

Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China

R Gu, Y Wang, S Wu, Y Wang, P Li, L Xu, Y Zhou… - BMC chemistry, 2019 - Springer
The medicinal plant Tirpitzia sinensis has been used by the Zhuang ethnic people in
mountainous areas of Southwest China to stop bleeding, invigorate blood circulation, and …

靶向IGF-1R 的siRNA 增强肺癌细胞对Trail 诱导凋亡敏感性的研究

刘黎明, 胡俊锋, 张永, 夏雪梅, 宫蓓蕾, 曹大龙 - 中华全科医学, 2016 - zhqkyx.net
目的研究IGF-1R 特异RNA 干扰后肺腺癌细胞A549 增殖和凋亡的改变以及其对Trail 的敏感性.
方法化学合成IGF-1R 特异siRNA 转录模板, 与表达载体连接, 转染大肠杆菌扩增后提取质粒 …

[PDF][PDF] Studying the chemosensitizing effect of Pirfenidone in non-small cell lung cancer cell lines

HI de Freitas Branco - 2021 - repositorio-aberto.up.pt
Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell
lung cancer (NSCLC) accounts for roughly 85% of the cases. Despite the advances that …