Therapeutic antibodies targeting disease-associated antigens are key tools in the treatment
of cancer and autoimmunity. So far, therapeutic antibodies have targeted antigens that are …

Lupus nephritis is a major organ manifestation of systemic lupus erythematosus (SLE) that
could lead to acute or chronic renal failure. Active lupus is characterized serologically by …

A unique subset of anti-DNA antibodies enters living cells, interacts with DNase 1, and
inhibits endonuclease activity, before their nuclear localization and subsequent attenuation …

Abstract Some Bence-Jones proteins have been found to be capable of hydrolyzing DNA,
chromogenic amide substrates, such as benzoylarginine p-nitroanilide, and natural …

The dogmatic and at one time prevalent concept that intact antibody molecules were not
able to enter into viable cells has now been modified due to the availability of a large …

The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic
functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme …

Methods The comet assay was used to quantify nuclear DNA damage in neutrophils from
SLE patients (n= 20), control subjects (n= 15) and RA patients (n= 15). Levels of DNA …

Autoantibodies against double stranded (ds) DNA are not only a helpful serological marker
for diagnosis of systemic lupus erythematosus (SLE), but have also been shown to be …

Various pathological processes are known to be associated with the production of IgG
autoantibodies, which have high affinity for self-antigens and often cause tissue injury and …

While anti-double-stranded (ds) DNA antibodies are a characteristic serologic hallmark for
SLE, the triggering antigen is unknown. Using phage display libraries, we identified …