The clever strategies used by intracellular parasites to hijack host gene expression
M Villares, J Berthelet, JB Weitzman - Seminars in Immunopathology, 2020 - Springer
Intracellular pathogens need to develop sophisticated mechanisms to survive and thrive in
the hostile environment within host cells. Unicellular, eukaryotic parasites from the …
the hostile environment within host cells. Unicellular, eukaryotic parasites from the …
A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment
Toxoplasma gondii has a complex life cycle that is typified by asexual development that
takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids and is …
takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids and is …
Mechanisms of adaptation and evolution in Toxoplasma gondii
Toxoplasma has high host flexibility, infecting all nucleated cells of mammals and birds. This
implies that during its infective process the parasite must constantly adapt to different …
implies that during its infective process the parasite must constantly adapt to different …
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
The development of malaria parasites throughout their various life cycle stages is
coordinated by changes in gene expression. We previously showed that the three …
coordinated by changes in gene expression. We previously showed that the three …
Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum
WAM Hoeijmakers, J Miao, S Schmidt… - Nucleic acids …, 2019 - academic.oup.com
Epigenetic regulatory mechanisms are central to the development and survival of all
eukaryotic organisms. These mechanisms critically depend on the marking of chromatin …
eukaryotic organisms. These mechanisms critically depend on the marking of chromatin …
Deciphering histone H4 lysine acetylation and methylation via sortase-mediated semisynthesis
Y Xiao, K Zou, J Yang, M Wu - Cell Reports Physical Science, 2023 - cell.com
The post-translational modifications of histone H4 play significant roles in regulation of
epigenetic status. Reconstituted nucleosomes that mimic the native chromatin are valuable …
epigenetic status. Reconstituted nucleosomes that mimic the native chromatin are valuable …
An apicomplexan bromodomain protein, TgBDP1, associates with diverse epigenetic factors to regulate essential transcriptional processes in Toxoplasma gondii
The protozoan pathogen Toxoplasma gondii relies on tight regulation of gene expression to
invade and establish infection in its host. The divergent gene regulatory mechanisms of …
invade and establish infection in its host. The divergent gene regulatory mechanisms of …
Histone variant H2B. Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness
Through regulation of DNA packaging, histone proteins are fundamental to a wide array of
biological processes. A variety of post-translational modifications (PTMs), including …
biological processes. A variety of post-translational modifications (PTMs), including …
Genome-wide localization of histone variants in Toxoplasma gondii implicates variant exchange in stage-specific gene expression
SC Nardelli, NC Silmon de Monerri, L Vanagas… - BMC genomics, 2022 - Springer
Background Toxoplasma gondii is a protozoan parasite that differentiates from acute
tachyzoite stages to latent bradyzoite forms in response to environmental cues that modify …
tachyzoite stages to latent bradyzoite forms in response to environmental cues that modify …
Single cell expression and chromatin accessibility of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential ribosome regulon driver
Sequential lytic cycles driven by cascading transcriptional waves underlie pathogenesis in
the apicomplexan parasite Toxoplasma gondii. This parasite's unique division by internal …
the apicomplexan parasite Toxoplasma gondii. This parasite's unique division by internal …