▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …

T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …

In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …

The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides
presented at the cell surface in the context of major histocompatibility complex (MHC) …

Virus infections and autoimmune disease have long been linked. These infections often
precede the occurrence of inflammation in the target organ. Several mechanisms often used …

It is commonly accepted that a high level of antigen specificity is a feature of T-cell activation.
However, here, Don Mason argues that a comprehensive response to foreign antigens …

Working memory is the process of maintaining an active representation of information so that
it is available for use. In monkeys, a prefrontal cortical region important for spatial working …

Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating
neurological disease. It has been considered to be an autoimmune disorder mediated by …

I present here a new model for the primary activation of precursor helper T cells.
Observations demonstrate that the immune system learns not to respond to extrathymic …

Molecular mimicry has been proposed as a pathogenetic mechanism for autoimmune
disease, as well as a probe useful in uncovering its etiologic agents. The hypothesis is …