This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Nearly twenty years ago, Dunitz and Bernstein described a selection of intriguing cases of
polymorphs that disappear. The inability to obtain a crystal form that has previously been …

Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

This Tutorial Review, aimed at both the novice and the seasoned solid-state chemist,
provides a succinct overview of key findings that have, over the last half century, advanced …

Control of intermolecular interactions is integral to harnessing self-assembly in nature. Here
we demonstrate that control of the competition between hydrogen bonds and halogen …

A significant amount of attention has been given to the design and synthesis of co‐crystals
by both industry and academia because of its potential to change a molecule's …

Mechanochemistry provides an efficient, but still poorly understood route to synthesize and
screen for polymorphs of organic solids. We present a hitherto unexplored effect of the …

Twenty years ago, I wrote a Chem. Commun. feature article entitled “Crystal Engineering:
where from? Where to?”: an update is in order. In this Highlight I argue that molecular crystal …

Mechanochemistry deals with reactions induced by the input of mechanical energy–for
example by impacts within a vibratory ball mill. The technique has a long history with …

Cocrystals are modular multicomponent solids with exceptional utility in synthetic chemistry
and materials science. A variety of methods exist for the preparation of cocrystals, yet, some …