[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …
several types of adipose tissue have been identified, namely white, brown, and beige, that …
Tissue homeostasis and inflammation
ML Meizlish, RA Franklin, X Zhou… - Annual review of …, 2021 - annualreviews.org
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …
inflammation. However, despite an abundance of data, the organizing principles of tissue …
Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy
metabolism, glucose tolerance, immune system maturation and function in humans …
metabolism, glucose tolerance, immune system maturation and function in humans …
The endocrine function of adipose tissues in health and cardiometabolic disease
L Scheja, J Heeren - Nature reviews endocrinology, 2019 - nature.com
In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …
Targeting interleukin-6 signaling in clinic
S Kang, T Tanaka, M Narazaki, T Kishimoto - Immunity, 2019 - cell.com
Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …
Pleiotropy and specificity: insights from the interleukin 6 family of cytokines
M Murakami, D Kamimura, T Hirano - Immunity, 2019 - cell.com
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …
Interleukin-6: designing specific therapeutics for a complex cytokine
Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …
functions that include regulation of immune cell proliferation and differentiation …
Targeting innate immune mediators in type 1 and type 2 diabetes
MY Donath, CA Dinarello… - Nature Reviews …, 2019 - nature.com
Type 1 and type 2 diabetes are characterized by chronic inflammation; both diseases
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …
Interleukin-6 family cytokines
S Rose-John - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …
Role of interleukin-6 in cancer progression and therapeutic resistance
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …
reduced significantly despite phenomenal advances in the technologies related to diagnosis …