Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Introduction The understanding of coagulopathies in trauma has increased interest in
thromboelastography (TEG®) and thromboelastometry (ROTEM®), which promptly evaluate …

Plasma utilization has increased over the past two decades, and there is a growing concern
that many plasma transfusions are inappropriate. Plasma transfusion is not without risk, and …

Within 3 months of the first diagnosed case, the outbreak of acute respiratory disease
caused by the novel coronavirus (SARS-CoV-2), also known as COVID-19, rapidly grew into …

Background: Massive bleeding and transfusion of packed red blood cells (PRBC), fresh
frozen plasma (FFP) and platelets are associated with increased morbidity, mortality and …

Bleeding is an important issue in cardiothoracic surgery, and about 20% of all blood
products are transfused in this clinical setting worldwide. Transfusion practices, however …

Acute lung injury and acute respiratory distress syndrome are clinical entities of multi-
factorial origin frequently seen in traumatically injured patients requiring intensive care. We …

Hemorrhage in the setting of severe trauma is a leading cause of death worldwide. The
pathophysiology of hemorrhage and coagulopathy in severe trauma is complex and remains …

Background Due to platelet availability limitations, platelet units ABO mismatched to
recipients are often transfused. However, since platelets express ABO antigens and are …

Thromboelastometry (ROTEM®) is an advancement of the classical thromboelastography.
Several technical enhancements made the device more robust and user-friendly, reduced …