[HTML][HTML] Ten Years of BrainAGE as a Neuroimaging Biomarker of Brain Aging: What Insights Have We Gained?

K Franke, C Gaser - Frontiers in neurology, 2019 - frontiersin.org
With the aging population, prevalence of neurodegenerative diseases is increasing, thus
placing a growing burden on individuals and the whole society. However, individual rates of …

[HTML][HTML] Machine learning for brain age prediction: Introduction to methods and clinical applications

L Baecker, R Garcia-Dias, S Vieira, C Scarpazza… - …, 2021 - thelancet.com
The rise of machine learning has unlocked new ways of analysing structural neuroimaging
data, including brain age prediction. In this state-of-the-art review, we provide an …

Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

ML Elliott, A Caspi, RM Houts, A Ambler, JM Broadbent… - Nature aging, 2021 - nature.com
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

Predicting age using neuroimaging: innovative brain ageing biomarkers

JH Cole, K Franke - Trends in neurosciences, 2017 - cell.com
The brain changes as we age and these changes are associated with functional
deterioration and neurodegenerative disease. It is vital that we better understand individual …

[HTML][HTML] Multimodality neuroimaging brain-age in UK biobank: relationship to biomedical, lifestyle, and cognitive factors

JH Cole - Neurobiology of aging, 2020 - Elsevier
The brain-age paradigm is proving increasingly useful for exploring aging-related disease
and can predict important future health outcomes. Most brain-age research uses structural …

Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker

JH Cole, RPK Poudel, D Tsagkrasoulis, MWA Caan… - NeuroImage, 2017 - Elsevier
Abstract Machine learning analysis of neuroimaging data can accurately predict
chronological age in healthy people. Deviations from healthy brain ageing have been …

[HTML][HTML] Brain age predicts mortality

JH Cole, SJ Ritchie, ME Bastin, V Hernández… - Molecular …, 2018 - nature.com
Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …

[HTML][HTML] Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

Predicting brain-age from multimodal imaging data captures cognitive impairment

F Liem, G Varoquaux, J Kynast, F Beyer, SK Masouleh… - Neuroimage, 2017 - Elsevier
The disparity between the chronological age of an individual and their brain-age measured
based on biological information has the potential to offer clinically relevant biomarkers of …

Deep learning-based brain age prediction in normal aging and dementia

J Lee, BJ Burkett, HK Min, ML Senjem, ES Lundt… - Nature Aging, 2022 - nature.com
Brain aging is accompanied by patterns of functional and structural change. Alzheimer's
disease (AD), a representative neurodegenerative disease, has been linked to accelerated …