The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously
expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …

α7-Nicotinic acetylcholine receptors have emerged as a potential therapeutic target for the
treatment of neurocognitive dysfunctions in schizophrenia that are often resistant to existing …

Spermatogonial stem cells exhibit a low level of spontaneous mutation that is heavily
impacted by paternal age via mechanisms that appear to involve the aberrant repair of DNA …

BACKGROUND: The rising population of individuals identified with an autism spectrum
disorder (ASD) calls for further investigation of its underlying etiology. A disturbance in the …

Objective: α7-Nicotinic receptors are involved in the final maturation of GABA inhibitory
synapses before birth. Choline at levels found in the amniotic fluid is an agonist at α7 …

Background We have recently identified the nuclear hormone receptor RORA (retinoic acid-
related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder …

Genomically identical cells have long been assumed to comprise the human brain, with post-
genomic mechanisms giving rise to its enormous diversity, complexity, and disease …

The α7 nicotinic receptor (α7 nAChR) is an important entry point for Ca 2+ into the cell,
which has broad and important effects on gene expression and function. The gene …

Objective To assess whether maternal choline decreases effects of mothers' infections on
fetal brain circuit development and on expression of infant behavior at 1 year of age. Study …

Autism is a neurodevelopmental disorder marked by social skills and communication deficits
and interfering repetitive behavior. Intellectual disability often accompanies autism. In …