Nearly all structures in our body experience mechanical forces. At a molecular scale, these
forces are detected by ion channels that function as mechanotransducers converting …

The cellular and systemic effects induced by bacterial lipopolysaccharides (LPS) have been
solely attributed to the activation of the Toll-like receptor 4 (TLR4) signalling cascade …

Sustained increase in intraocular pressure represents a major risk factor for eye disease, yet
the cellular mechanisms of pressure transduction in the posterior eye are essentially …

Transient receptor potential (TRP) channels mediate a wide array of sensory functions. We
investigated the role of TRPC5, a poorly characterized channel widely expressed in the …

In smooth muscle cells, agonists such as neurotransmitters or hormones can induce an
increase in [Ca2+] i via a release of intracellular stored calcium or/and an influx of …

The overall perception of flavor results from the integration of taste, smell, and
somatosensory information streaming out of specialized receptor cells located in the …

Excessive loading of ligaments can activate the neural afferents that innervate the
collagenous tissue, leading to a host of pathologies including pain. An integrated …

purpose. The lamina cribrosa (LC) region of the optic nerve head is considered the primary
site of damage in glaucomatous optic neuropathy. Resident LC cells have a profibrotic …

The interconnection between vision and somatosensation is already well-established and is
further supplemented by the evolutionary link between eyes and photoreceptors, and the …

Sustained increase in intraocular pressure represents a major risk factor for eye disease yet
the cellular mechanisms of pressure transduction in the posterior eye are essentially …