Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

RJ Obaid, N Naeem, EU Mughal, MM Al-Rooqi… - RSC …, 2022 - pubs.rsc.org
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …

Pharmacological significance of nitrogen-containing five and six-membered heterocyclic scaffolds as potent cholinesterase inhibitors for drug discovery

RJ Obaid, EU Mughal, N Naeem, MM Al-Rooqi… - Process …, 2022 - Elsevier
N-heterocycles are crucial due to their biological, chemical, and practical significance. They
are heavily investigated in biological processes involving anticancer, anti-inflammatory …

[HTML][HTML] Advancement of chitin and chitosan as promising biomaterials

MM Al-Rooqi, MM Hassan, Z Moussa, RJ Obaid… - Journal of Saudi …, 2022 - Elsevier
Biopolymers like cellulose, polysaccharides, chitosan, starch, chitin, and alginates have
sparked an increasing curiosity in creating natural replacements for synthetic polymers …

[HTML][HTML] In vitro and in silico evaluation of the antimicrobial and antioxidant activities of spiropyrazoline oxindole congeners

M Chalkha, K Chebbac, H Nour, A Nakkabi… - Arabian Journal of …, 2024 - Elsevier
The search for novel powerful antimicrobial and antioxidant agents is considered a dynamic
field in medicinal chemistry. In this context, a series of spiropyrazoline indolin-3-one …

Novel cis‐Pt (II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action

J Kasparkova, H Kostrhunova… - Bioinorganic …, 2022 - Wiley Online Library
One concept of improving anticancer effects of conventional platinum‐based antitumor
drugs consists of conjugating these compounds with other biologically (antitumor) active …

New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights

MS Malik, RI Alsantali, QMS Jamal, ZS Seddigi… - Frontiers in …, 2022 - frontiersin.org
An efficient atom-economical synthetic protocol to access new imidazole-based N-
phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized …

Role of pharmacological active phthalazine scaffolds in medicinal chemistry

SMN Sakib - Open Science Foundation, 2023 - osf.io
Phthalazine derivatives have recently received a lot of interest in the realm of physiologically
active chemical research. Introduce this phthalazine moiety to a researcher in a new …

[HTML][HTML] Ionic liquid mediated four-component synthesis of novel phthalazinone based indole-pyran hybrids as cytotoxic agents

MS Malik, RI Alsantali, MA Alsharif, SI Aljayzani… - Arabian Journal of …, 2022 - Elsevier
A robust design and synthesis of novel phthalazinone based indole-pyran hybrids as
cytotoxic agents is described. A relatively safer ionic liquid medium ([BMIM] BF 4) was …

Design, synthesis, molecular docking, ADMET studies, and biological activity evaluation of new 2-({[3-aryl-1, 2, 4-oxadiazol-5-yl) methyl] thio}-1H-benzimidazoles and …

M Sharaf, AH Moustafa, RJ Obaid… - Journal of Molecular …, 2024 - Elsevier
Aryl amidoximes are active binucleophilic compounds used as a powerful and versatile
reagent in synthesizing diverse heterocyclic compounds with pharmacological interest …

Antibacterial Properties and Computational Insights of Potent Novel Linezolid-Based Oxazolidinones

MS Malik, S Faazil, MA Alsharif, QM Sajid Jamal… - Pharmaceuticals, 2023 - mdpi.com
The mounting evidence of bacterial resistance against commonly prescribed antibiotics
warrants the development of new antibacterial drugs on an urgent basis. Linezolid, an …