Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI

DK Jones, DC Alexander, R Bowtell, M Cercignani… - NeuroImage, 2018 - Elsevier
The key component of a microstructural diffusion MRI 'super-scanner'is a dedicated high-
strength gradient system that enables stronger diffusion weightings per unit time compared …

Q-space trajectory imaging for multidimensional diffusion MRI of the human brain

CF Westin, H Knutsson, O Pasternak… - Neuroimage, 2016 - Elsevier
This work describes a new diffusion MR framework for imaging and modeling of
microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of …

Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail

H Lundell, M Nilsson, TB Dyrby, GJM Parker… - Scientific reports, 2019 - nature.com
Abstract Characterization of porous media is essential in a wide range of biomedical and
industrial applications. Microstructural features can be probed non-invasively by diffusion …

[HTML][HTML] The dot-compartment revealed? Diffusion MRI with ultra-strong gradients and spherical tensor encoding in the living human brain

CMW Tax, F Szczepankiewicz, M Nilsson, DK Jones - Neuroimage, 2020 - Elsevier
The so-called “dot-compartment” is conjectured in diffusion MRI to represent small spherical
spaces, such as cell bodies, in which the diffusion is restricted in all directions. Previous …

Validation strategies for the interpretation of microstructure imaging using diffusion MRI

TB Dyrby, GM Innocenti, M Bech, H Lundell - Neuroimage, 2018 - Elsevier
Extracting microanatomical information beyond the image resolution of MRI would provide
valuable tools for diagnostics and neuroscientific research. A number of mathematical …

Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia‐ischemia injured mouse brains

D Wu, LJ Martin, FJ Northington… - Magnetic resonance in …, 2014 - Wiley Online Library
Purpose We investigated whether oscillating gradient diffusion MRI (dMRI) can provide
information on brain microstructural changes after formaldehyde fixation and after hypoxic …

Human cerebellar sub-millimeter diffusion imaging reveals the motor and non-motor topography of the dentate nucleus

CJ Steele, A Anwander, PL Bazin, R Trampel… - Cerebral …, 2017 - academic.oup.com
The reciprocal cortico-cerebellar loops that underlie cerebellar contributions to motor and
cognitive behavior form one of the largest systems in the primate brain. Work with non …

[HTML][HTML] Nonparametric distributions of tensor-valued Lorentzian diffusion spectra for model-free data inversion in multidimensional diffusion MRI

O Narvaez, M Yon, H Jiang, D Bernin… - The Journal of …, 2024 - pubs.aip.org
Magnetic resonance imaging (MRI) is the method of choice for noninvasive studies of
micrometer-scale structures in biological tissues via their effects on the time-and frequency …

[HTML][HTML] Diffusion time dependency along the human corpus callosum and exploration of age and sex differences as assessed by oscillating gradient spin-echo …

P Tétreault, KD Harkins, CA Baron, R Stobbe, MD Does… - Neuroimage, 2020 - Elsevier
Conventional diffusion imaging uses pulsed gradient spin echo (PGSE) waveforms with
diffusion times of tens of milliseconds (ms) to infer differences of white matter microstructure …