Biofilms are complex bacterial communities that resist the action of antibiotics and the
human immune system. Bacteria within biofilms are the cause of numerous, almost …

Pyoverdines are a group of structurally related siderophores produced by fluorescent
Pseudomonas species. Recent genomic and biochemical data have shed new light on the …

The sputum (mucus) layer of the cystic fibrosis (CF) lung is a complex substrate that provides
Pseudomonas aeruginosa with carbon and energy to support high-density growth during …

A vexing problem in cystic fibrosis (CF) pathogenesis has been to explain the high
prevalence of Pseudomonas aeruginosa biofilms in CF airways. We speculated that airway …

Pseudomonas aeruginosa airway infections are a major cause of mortality and morbidity of
cystic fibrosis (CF) patients. In order to persist, P. aeruginosa depends on acquiring iron from …

The ability of Pseudomonas aeruginosa to form antibiotic-resistant biofilms is thought to
account for the inability of current therapies to resolve bacterial infections in the lungs of …

Pancreatic exocrine insufficiency (PEI) frequently occurs secondary to exocrine pancreatic
disease (eg chronic pancreatitis, cystic fibrosis, cancer) or pancreatic/gastrointestinal …

When grown in divalent cation-limited medium, Pseudomonas aeruginosa becomes
resistant to cationic antimicrobial peptides and polymyxin B. This resistance is regulated by …

Bacterial biofilms are thought to aid in the survivability of a variety of intractable infections in
humans. Specifically, biofilm production in Pseudomonas aeruginosa has been shown to …

Enhanced antibiotic resistance of Pseudomonas aeruginosa in the cystic fibrosis (CF) lung
is thought to be due to the formation of biofilms. However, there is no information on the …