Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

The KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A–KDM4D),
which selectively remove the methyl group (s) from tri/dimethylated lysine 9/36 of H3 …

A novel iridium (III) complex was synthesized and evaluated for its ability to target JMJD2
enzymatic activity. The iridium (III) complex 1 can inhibit JMJD2 activity and was selective for …

Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is
critical for malaria parasite survival in multiple life stages and a promising target for new …

Development of tool molecules that inhibit Jumonji demethylases allows for the investigation
of cancer-associated transcription. While scaffolds such as 2, 4-pyridinedicarboxylic acid (2 …

Pathogenic coronaviruses are a major threat to global public health. Here, using a
recombinant reporter virus-based compound screening approach, we identified small …

The increasing drug resistance of Mycobacterium tuberculosis (Mtb), coupled with the
limited availability of effective anti-tuberculosis medications, poses significant challenges for …

Epigenetic regulation of gene expression is essential in many biological processes, and its
deregulation contributes to pathology including tumor formation. We used an image-based …