Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

PG Arnison, MJ Bibb, G Bierbaum, AA Bowers… - Natural product …, 2013 - pubs.rsc.org
Covering: 1988 to 2012 This review presents recommended nomenclature for the
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …

Cyclotides: from structure to function

SJ De Veer, MW Kan, DJ Craik - Chemical reviews, 2019 - ACS Publications
This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Natural products as antifouling compounds: recent progress and future perspectives

PY Qian, Y Xu, N Fusetani - Biofouling, 2009 - Taylor & Francis
Since early 2008, an increasing number of countries have ratified an international treaty to
ban the application of antifouling (AF) coatings based on organotin compounds (eg …

The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria

M Pränting, C Lööv, R Burman… - Journal of …, 2010 - academic.oup.com
Objectives To determine the antibacterial activity of small cyclic plant proteins, ie cyclotides,
and the importance of the surface exposed charged residues for activity. Methods Prototypic …

Distribution and evolution of circular miniproteins in flowering plants

CW Gruber, AG Elliott, DC Ireland, PG Delprete… - The Plant …, 2008 - academic.oup.com
Cyclotides are disulfide-rich miniproteins with the unique structural features of a circular
backbone and knotted arrangement of three conserved disulfide bonds. Cyclotides have …

An asparaginyl endopeptidase mediates in vivo protein backbone cyclization

I Saska, AD Gillon, N Hatsugai, RG Dietzgen… - Journal of Biological …, 2007 - ASBMB
Proteases can catalyze both peptide bond cleavage and formation, yet the hydrolysis
reaction dominates in nature. This presents an interesting challenge for the biosynthesis of …

Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins

AG Poth, ML Colgrave, R Philip, B Kerenga… - ACS chemical …, 2011 - ACS Publications
Cyclotides are plant proteins whose defining struc-tural features are a head-to-tail cyclized
backbone and three interlocking disulfide bonds, which in combination are known as a …

Discovery, structure, function, and applications of cyclotides: circular proteins from plants

J Weidmann, DJ Craik - Journal of Experimental Botany, 2016 - academic.oup.com
Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …

Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides

S Gunasekera, FM Foley, RJ Clark… - Journal of medicinal …, 2008 - ACS Publications
Cyclotides are plant derived mini-proteins with compact folded structures and exceptional
stability. Their stability derives from a head-to-tail cyclized backbone coupled with a cystine …

Backbone Cyclised Peptides from Plants Show Molluscicidal Activity against the Rice Pest Pomacea canaliculata (Golden Apple Snail)

MRR Plan, I Saska, AG Cagauan… - Journal of agricultural …, 2008 - ACS Publications
Golden apple snails (Pomacea canaliculata) are serious pests of rice in South East Asia.
Cyclotides are backbone cyclized peptides produced by plants from Rubiaceae and …