Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Covering: 1988 to 2012 This review presents recommended nomenclature for the
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …
Cyclotides: from structure to function
SJ De Veer, MW Kan, DJ Craik - Chemical reviews, 2019 - ACS Publications
This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …
include an account of their discovery, characterization, and distribution in the plant kingdom …
Natural products as antifouling compounds: recent progress and future perspectives
Since early 2008, an increasing number of countries have ratified an international treaty to
ban the application of antifouling (AF) coatings based on organotin compounds (eg …
ban the application of antifouling (AF) coatings based on organotin compounds (eg …
The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria
M Pränting, C Lööv, R Burman… - Journal of …, 2010 - academic.oup.com
Objectives To determine the antibacterial activity of small cyclic plant proteins, ie cyclotides,
and the importance of the surface exposed charged residues for activity. Methods Prototypic …
and the importance of the surface exposed charged residues for activity. Methods Prototypic …
Distribution and evolution of circular miniproteins in flowering plants
Cyclotides are disulfide-rich miniproteins with the unique structural features of a circular
backbone and knotted arrangement of three conserved disulfide bonds. Cyclotides have …
backbone and knotted arrangement of three conserved disulfide bonds. Cyclotides have …
An asparaginyl endopeptidase mediates in vivo protein backbone cyclization
I Saska, AD Gillon, N Hatsugai, RG Dietzgen… - Journal of Biological …, 2007 - ASBMB
Proteases can catalyze both peptide bond cleavage and formation, yet the hydrolysis
reaction dominates in nature. This presents an interesting challenge for the biosynthesis of …
reaction dominates in nature. This presents an interesting challenge for the biosynthesis of …
Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins
AG Poth, ML Colgrave, R Philip, B Kerenga… - ACS chemical …, 2011 - ACS Publications
Cyclotides are plant proteins whose defining struc-tural features are a head-to-tail cyclized
backbone and three interlocking disulfide bonds, which in combination are known as a …
backbone and three interlocking disulfide bonds, which in combination are known as a …
Discovery, structure, function, and applications of cyclotides: circular proteins from plants
J Weidmann, DJ Craik - Journal of Experimental Botany, 2016 - academic.oup.com
Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …
Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides
S Gunasekera, FM Foley, RJ Clark… - Journal of medicinal …, 2008 - ACS Publications
Cyclotides are plant derived mini-proteins with compact folded structures and exceptional
stability. Their stability derives from a head-to-tail cyclized backbone coupled with a cystine …
stability. Their stability derives from a head-to-tail cyclized backbone coupled with a cystine …
Backbone Cyclised Peptides from Plants Show Molluscicidal Activity against the Rice Pest Pomacea canaliculata (Golden Apple Snail)
MRR Plan, I Saska, AG Cagauan… - Journal of agricultural …, 2008 - ACS Publications
Golden apple snails (Pomacea canaliculata) are serious pests of rice in South East Asia.
Cyclotides are backbone cyclized peptides produced by plants from Rubiaceae and …
Cyclotides are backbone cyclized peptides produced by plants from Rubiaceae and …