The human intestine contains huge amounts of nonpathologic bacteria surviving in an
environment that is beneficial to both the host and the bacterial populations. In the normal …

The intestine plays a fundamental role as a regulator of the mucosal immune response,
mostly through the production and secretion of secretory Immunoglobulin A (sIgA) by the gut …

Introduction Nutrition support is an integral component of modern patient care. Type and
route of nutritional support impacts clinical infectious outcomes in critically injured patients …

BACKGROUND: Both humans and mice increase airway immunoglobulin A (IgA) after
injury. This protective response is associated with TNF-α, IL-1β, and IL-6 airway increases …

Approximately one-half million uncontrolled infections occur per year, costing the United
States annual health care budget $10–20 billion; sepsis remains the leading cause of death …

To determine the salivary secretory immunoglobulin A (sIgA) response to repeated bouts of
unaccustomed, downhill running (eccentrically biased) and examine potential protective …

Background: Outbred mice exhibit increased airway and intestinal immunoglobulin A (IgA)
following injury when fed normal chow, consistent with humans. Parenteral nutrition (PN) …

Background: Injury stimulates an innate airway IgA response in severely injured patients,
which also occurs in mice. Tumor necrosis factor (TNF)-α and interleukin (IL)-1β stimulate …

Objective: To determine effects of (1) parenteral nutrition (PN),(2) exogenous Lymphotoxin β
receptor (LTβR) stimulation in PN animals, and (3) exogenous LTβR blockade in chow …

BACKGROUND: Parenteral nutrition (PN) increases post-trauma pneumonia versus enteral
feeding. PN impairs murine immunoglobulin A (IgA) airway defenses and abrogates a …