Tobacco smoke contains multiple classes of established carcinogens including benzo (a)
pyrenes, polycyclic aromatic hydrocarbons, and tobacco-specific nitrosamines. Most of these …

Animal life is controlled by neurons and in this setting cholinergic neurons play an important
role. Cholinergic neurons release ACh, which via nicotinic and muscarinic receptors (n‐and …

To identify risk variants for lung cancer, we conducted a multistage genome-wide
association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 …

Cigarette smoking is strongly correlated with the onset of nonsmall cell lung cancer
(NSCLC). Nicotine, an active component of cigarettes, has been found to induce …

Nicotinic acetylcholine receptors (nAChRs) are the central regulators of stimulatory and
inhibitory neurotransmitters that control the synthesis and release of growth, angiogenic and …

Recent studies have shown that nicotine, a component of cigarette smoke, can stimulate the
proliferation of non-neuronal cells. While nicotine is not carcinogenic by itself, it has been …

Non-small cell lung cancer (NSCLC) demonstrates a strong etiologic association with
smoking. Although nicotine is not carcinogenic, it can induce cell proliferation and …

Nicotinic acetylcholine receptors (nAChRs) constitute a heterogeneous family of ion
channels that mediate fast synaptic transmission in neurons. They have also been found on …

Nicotine enters the environment mainly through human activity, as well as natural sources.
This review article examines the increasing evidence implicating nicotine in the initiation …

Nerve fibers accompany blood and lymphatic vessels all over the body. An extensive
amount of knowledge has been obtained with regard to tumor angiogenesis and tumor …