RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and
have been demonstrated to be very successful in combating viral infections in clinic …

Most cases of adult myeloid neoplasms are routinely assumed to be sporadic. Here, we
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

Traditional functions of DExD/H-box helicases are concerned with RNA metabolism; they
have been shown to play a part in nearly every cellular process that involves RNA. On the …

Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/β-
catenin signaling. They phosphorylate several pathway components and exert a dual …

The DEAD-box RNA helicase DDX3 is a multifunctional protein involved in all aspects of
RNA metabolism, including transcription, splicing, mRNA nuclear export, translation, RNA …

Targeting a host factor essential for the replication of different viruses but not for the cells
offers a higher genetic barrier to the development of resistance, may simplify therapy …

Cancer is one of the most studied areas of human biology over the past century. Despite
having attracted much attention, hype, and investments, the search to find a cure for cancer …

The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …