Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Highlights•Modulation of synaptic strength can occur through changes in short-term
plasticity.•Modulators can shape or induce long-term synaptic plasticity.•Modulators can …

Malignant migrating partial seizures of infancy (MMPSI) is a rare epileptic encephalopathy of
infancy that combines pharmacoresistant seizures with developmental delay. We performed …

Objective Mutations in KCNT1 have been implicated in autosomal dominant nocturnal
frontal lobe epilepsy (ADNFLE) and epilepsy of infancy with migrating focal seizures …

Abstract High-conductance,'big'potassium (BK) channels encoded by the Slo gene family
are among the largest and most complex of the extended family of potassium channels. The …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

Summary The sodium-activated Slo2. 2 channel is abundantly expressed in the brain,
playing a critical role in regulating neuronal excitability. The Na+-binding site and the …

Mutations in the KCNT1 (Slack, KNa1. 1) sodium-activated potassium channel produce
severe epileptic encephalopathies. Expression in heterologous systems has shown that the …

A subset of potassium channels is regulated primarily by changes in the cytoplasmic
concentration of ions, including calcium, sodium, chloride, and protons. The eight members …